2024 Tog domain

Tog domain

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August undefined, 2024

WebJul 15, 2008 · One TOG domain contains six HEAT repeats, each comprised of a pair of parallel helices (Al-Bassam et al., 2007). A single TOG domain from yeast XMAP215 homologue Stu2p is capable of binding α-tubulin–β-tubulin heterodimers ( Al-Bassam et al., 2007 ), whereas XMAP215 with five TOG domains binds the tubulin dimer in a 1:1 … WebNov 26, 2024 · The x-ray crystal structures of human CLASP1 TOG1 and TOG2 are presented to highlight the structural diversity of TOG domains within the CLASp TOG array and provide a molecular foundation for understandingCLASP-dependent effects on microtubule dynamics. Tubulin-binding TOG domains are found arrayed in a number of …

Structures of TOG1 and TOG2 from the human microtubule …

WebFeb 16, 2024 · By searching databases for TOG domain array-containing proteins, Das et al. (2015) identified human and mouse TOGARAM1, which they called Crescerin-1 after the Latin 'crescere' (grow). Human and mouse Crescerin-1 contain 1,773 and 1,776 amino acids, respectively. Both have an N-terminal pair of TOG domains and a C-terminal pair of … WebJul 2, 2024 · Mammalian CLASPs encompass three TOG-like domains, TOG1, TOG2, and TOG3, none of which bind to free tubulin. TOG2 is essential for catastrophe suppression, … hinib caps

Structures of TOG1 and TOG2 from the human microtubule …

WebMay 24, 2024 · TOG-domain proteins Curr Biol. 2024 May 24;31(10):R499-R501. doi: 10.1016/j.cub.2024.01.039. Authors Veronica J Farmer 1 , Marija Zanic 2 Affiliations 1 … WebAug 17, 2012 · The ability to function as a catalyst for microtubule elongation suggests that XMAP215/Stu2p family proteins use their tubulin-binding TOG domains to distinguish between at least three different forms of αβ-tubulin: unpolymerized, in the body of the microtubule, and at the growing end of the microtubule. hinh youtube

Regulation of microtubule dynamics by TOG-domain proteins

WebIn strains with targeted mutations of Che12 TOG domains, mutant Che12 properly localized to cilia, but the mutants otherwise phenocopied the Che12 deletion strain. Das et al. (2015) concluded that the TOG domain tubulin-binding activity of Che12 is required for proper sensory cilia development and cilia-based chemotactic function in C. elegans. WebJul 19, 2024 · Tubulin-binding TOG domains are found arrayed in a number of proteins that regulate microtubule dynamics. While much is known about the structure and function of … homeopathy for old ageWebThe TOG domain arrays in XMAP215 family of proteins bind to free tubulin dimers, and promote their stable incorporation onto MT plus-ends while the basic linker regions separating the TOG domains ... hinichen com

"Webincluding MOR1, have five TOG domains as well as a conserved C-terminal domain but in nematodes and yeasts, the number of TOG domains has been reduced to three and two, respectively, and the C-terminal regions are divergent. Both GFP tagging (Popov et al., 2001) and antibody labelling (Tournebize et al., 2000) localise Xenopus laevis MAP215 ... " - Tog domain

Tog domain

WebMay 24, 2024 · TOG domains often function in ordered arrays, with individual proteins containing as many as five distinct TOG domains, as is the case for XMAP215. While there is high sequence variability among different TOG domains, the intra-HEAT repeat loops … WebMay 31, 2024 · Microtubules are heavily regulated dynamic polymers of αβ-tubulin that are required for proper chromosome segregation and organization of the cytoplasm. Polymerases in the XMAP215 family use arrayed TOG domains to promote faster microtubule elongation. Regulatory factors in the cytoplasmic linker associated protein …

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WebJul 19, 2024 · Tubulin-binding TOG domains are found arrayed in a number of proteins that regulate microtubule dynamics. While much is known about the structure and function of … WebTOG-domain proteins Veronica J. Farmer1 and Marija Zanic1,2,* What are TOG-domain proteins? TOG-domain proteins are a class of proteins that contain at least one tumor …

WebJan 18, 2024 · Identification of a TOG domain–containing protein required for full flagellar length. During the course of screening mutants obtained from the Chlamydomonas … WebSep 1, 2024 · The MEKK1 TOG domain binds to tubulin heterodimers-a canonical function of TOG domains-but is unusual in that it appears alone rather than as part of a multi-TOG array, and has structural features distinct from previously characterized TOG domains. MEKK1 TOG demonstrates a clear preference for binding curved tubulin heterodimers, …

WebJan 18, 2024 · Identification of a TOG domain–containing protein required for full flagellar length. During the course of screening mutants obtained from the Chlamydomonas Library Project (CLiP) (Li et al., 2024), we found a mutant strain with shorter flagella than that of wild-type (WT) cells that we provisionally refer to as shf-A ().Flagella in these mutant … WebJun 4, 2013 · The TOG domain face composed of intra-HEAT loops forms a contiguous, conserved tubulin-binding surface. Nested within the conserved intra-HEAT loop 1 is an invariant, signature, ...

WebFeb 26, 2015 · TOG domains contain six HRs (A–F) with tubulin-binding residues located in the intra-HEAT loops that line one face of the domain (37,– 39). TOG3 is highly conserved across species with 35% of the residues in the domain having 80% cross-species identity. The highest areas of conservation map to the intra-HEAT loops.

WebThe molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the dynamic properties of microtubules (MTs) are still poorly understood. We review recent … hinh ve xe otoWebApr 8, 2024 · Here we show that MEKK1 contains a previously unidentified tumour overexpressed gene (TOG) domain. The MEKK1 TOG domain binds to tubulin heterodimers—a canonical function of TOG domains—but is unusual in that it appears alone rather than as part of a multi-TOG array, and has structural features distinct from … hinice bluetooth necklaceWebThe molecular mechanisms by which microtubule-associated proteins (MAPs) regulate the dynamic properties of microtubules (MTs) are still poorly understood. We review recent advances in our understanding of two conserved families of MAPs, the XMAP215/Dis1 and CLASP family of proteins. In vivo and in vitro studies show that XMAP215 proteins act ... hiniborchWebNov 13, 2024 · TOG1 and TOG2 domains were identified after cycles of density modification as described above. Four αβ-tubulins, four TOG domains, and two DRPΔN models were … hinichen youtubeWebStructure. The basic structure of the protein family consists of TOG (Tumor Overexpressed Gene) domains, ranging from 2-5 units.The family is categorized into three groups … hinh win 11 fhdWebJan 31, 2011 · Members of the XMAP215/Dis1 family are characterized by a varying number of TOG domains at their N termini ().Based on mutants in TOG domains that interfere … hinic morsbachWebAug 16, 2024 · N-terminal region of Cls1p indeed contains two active Tumor Overexpressed Gene (TOG) domains that are similar to XMAP215 TOG domains. A Cls1p dimer binds a single αβ-tubulin heterodimer through two sets of TOG domains, and to the MT lattice through a serine arginine-rich domain. Despite this similarity, Cls1p behaves very … homeopathy for pcos and pregnancy