WebJun 9, 2009 · The 35 probes regulated by both wild-type STAT1 and Y701F-STAT1 represent 30 distinct genes. More than half of these (17 of 30) function in immune responses . The functions of the other genes, including HERC6, FLJ20035, and EPSTI1, are mostly unknown. The signal for STAT1 itself was also increased in response to high STAT1 expression. WebSTAT1 Y701F and S727A mutants could be ubiquitinated and degraded by Smurf1 with the same efficiency as the WT STAT1. Thus, our findings suggest that Smurf1 is a cellular ubiquitin ligase with specificity toward unphosphorylated STAT1 proteins. Smurf1 plays essential roles in development (22.
Frontiers JAK/STAT Cytokine Signaling at the Crossroad of NK …
WebMay 18, 2012 · STAT1 Y701F and S727A mutants could be ubiquitinated and degraded by Smurf1 with the same efficiency as the WT STAT1. Thus, our findings suggest that Smurf1 is a cellular ubiquitin ligase with specificity toward unphosphorylated STAT1 proteins. Smurf1 plays essential roles in development . The possible role of the Smurf1 protein in … WebJan 19, 2024 · The antiviral response to IAV infection is also significantly suppressed in the STAT1 Y701F knockin mice. The results demonstrate that STAT1 activation is dependent … feral cats forever homes
Response to interferons and antibacterial innate immunity in the ...
WebSTAT1 alpha Y701F Alt name STAT1a Alt name STAT1 alpha Species H. sapiens (human) Insert Size (bp) 2400 Mutation Y701F GenBank ID M97935 Entrez Gene STAT1 ( a.k.a. … WebNov 15, 2016 · Approximately 1 × 10 5 cells were cultured on six‐well plate and transfected with eGFP STAT1 S727A or eGFP STAT1 Y701F plasmids (gifts from Alan Perantoni 40, … WebISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II … feral cat shelter building plans