Spare receptor theory
Web1. dec 2004 · Agonists and ED 50. An agonist is a drug that binds to a receptor and produces a functional response. Examples include morphine (μ-opioid receptor) and clonidine (α 2 -adrenoceptor). The ability to … Web27. nov 2024 · In the cardiovascular system, spare adenosine receptors appear to compensate for a low extracellular adenosine level and/or a low adenosine receptor number, such as in coronary artery disease...
Spare receptor theory
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WebThereby, the spare receptor model can be designed as a signal amplification system in which the effectiveness of the response to different ligands, full or partial agonists and possibly inverse agonist, can be quite complex due to the mixing of the effects of partial activation of receptors with those of signal transduction [ 26 ]. WebSpare Receptors [ edit] In some receptor systems (e.g. acetylcholine at the neuromuscular junction in smooth muscle), agonists are able to elicit maximal response at very low levels of receptor occupancy (<1%). Thus, that system has spare receptors or a receptor reserve.
WebSpare receptors If, as in the above example, some of the receptors can be in-activated without a decrease in the maximal effect, the dis-pensble receptor fraction is commonly referred to as `spare receptors'. Despite its widespread use in the literature, the term is not very precisely defined, and some argument ex-ists about its proper use. Web19. mar 2002 · Because of this large receptor reserve, T cells seem to be a functional model of the spare receptor theory. In this model, a full agonist does not need to occupy all receptors to achieve a maximal response, whereas partial agonists/weak agonists require more receptors to respond (22, 44).
WebSpare Receptors. A recent publication in the Clinical and Experimental Pharmacology & Physiology by Ferguson et al. (1979) concerned the application of receptor theory to … WebCurrent receptor theories try to relate drug effects to the interaction of a drug molecule with its specific receptor. While many theories have evolved and are explained in great detail in other chapters of this book, most are derived from the widely accepted and broadly based occupation theory by Clark (1937) and the laws of mass action. The most important …
Web1. dec 1979 · Spare Receptors Spare Receptors Madsen, B. W. 1979-12-01 00:00:00 A recent publication in the Clinical and Experimental Pharmacology & Physiology by Ferguson et al. …
WebThe presence of " spare receptors " lowers the concentration of hormone needed to produce a half-maximal response below that needed to produce half-saturation of receptor binding … hostile work environment definition georgiaWeb1. apr 1993 · However, the first recognition of “receptor reserve” or “spare receptors” mainly by Furchgott and Stephenson in separate studies about two decades ago has profoundly modified the original receptor occupancy theory, that is, the receptor occupancy is not directly proportional to the responses, and the ED 50 (orEC 50) could be much lower ... hostile work environment definition floridaWeb1. feb 2005 · As found, the spare receptor theory explains how pregnancies cope with such extreme variations in concentration. Under the spare receptor theory, when a small … hostile work environment definition opmWebClark’s theory of occupancy may also be used for examining responses, ... This phenomenon is called the spare receptor concept or receptor reserve. It is demonstrated … hostile work environment employee rightshostile work environment definitionsWebSpare receptors are present as the inactive receptor-ligand complex. Such a model is shown to fit already published data on membrane binding of alpha 1-adrenergic agonists as well … psychology textbook by openstaxWebTo date, the receptor reserve phenomenon has been characterized in an increasing number of receptor systems. In theory, spare receptors may influence the profile of dose … psychology textbook class 12