Splet07. feb. 2007 · The PDZ and LIM domain-containing protein family is encoded by a diverse group of genes whose phylogeny has currently not been analyzed. In mammals, ten genes are found that encode both a PDZ- and one or several LIM-domains. Splet14. nov. 2024 · Through WES, we identified LIM domain-binding protein 3 (LDB3) mutations (R547Q and P323S) respectively in an 11-year-old HCM girl and a 6-year-old HCM boy. Neural network analyses showed that the LDB3 (R547Q and P323S) mutation decreased its protein stability, with confidence scores of −0.9211 and −0.8967.
Frontiers Case Report: Novel LIM domain-binding protein 3 (LDB3 …
Splet26. jul. 1999 · PDZ motifs are modular protein-protein interaction domains, consisting of 80-120 amino acid residues, whose function appears to be the direction of intracellular proteins to multiprotein complexes. In skeletal muscle, there are a few known PDZ-domain proteins, which include neuronal nitric oxide syn … SpletPurpose: To characterize properties of Pdlim2, a novel PDZ and LIM domain-containing protein. Methods: cDNA encoding Pdlim2 was identified in a cDNA library of transcripts expressed in the tissues of the rat eye irido-corneal angle. The expression pattern of the Pdlim2 gene was studied by Northern blot analysis and in situ hybridization. how far is alva ok from okc
Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins …
Actin-associated LIM protein (ALP), also known as PDZ and LIM domain protein 3 is a protein that in humans is encoded by the PDLIM3 gene. ALP is highly expressed in cardiac and skeletal muscle, where it localizes to Z-discs and intercalated discs. ALP functions to enhance the crosslinking of actin by alpha-actinin-2 … Prikaži več ALP exists primarily as two alternatively spliced variants; a 39.2 kDa (364 amino acids) protein in skeletal muscle and a 34.3 kDa (316 amino acids) protein in cardiac muscle and smooth muscle. ALP has a N-terminal PDZ … Prikaži več Studies have shown that ALP is present at the first stage of myofibrilogenesis where it is bound to alpha actinin-2, and this association remains intact in mature myofibrils where … Prikaži več • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. • Xia H, Winokur ST, Kuo … Prikaži več Chromosome 4 pericentric inversion has been observed in 10 patients, with associated cardiac defects linked to terminal 4q35.1 deletions, which may affect PDLIM3. Prikaži več ALP interacts with: • Alpha-actinin-2 • Beta-catenin Prikaži več SpletPDZ Domain. PDZ domains are well-defined structural motifs of around 80–90 amino acids organized in six β-sheets (βA–βF) and two α-helices (αA, αB).46,47 PDZ … SpletPostsynaptic density 95, discs large and zonula occludens-1 (PDZ) and Lin-11, Isl1 and Mec-3 (LIM) domains, two common motifs that mediate protein–protein interactions, have been found to be of fundamental importance for multiple biological processes. how far is alva from okc