2024 Klf4 microglia

Klf4 microglia

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WebMay 6, 2024 · KLF4 is expressed in a variety of cell types including monocytes/macrophages. Previous reports have demonstrated that KLF4 is expressed in microglia and functions as a downstream factor of TLR signaling, plays critical roles in microglial activation, and ensuing neuroinflammation [ 38, 39, 40, 41 ]. WebApr 30, 2024 · Mechanistically, we identify Kruppel-like factor 4 (KLF4) as a key transcription factor that regulates cardiac resident macrophage proliferation and angiogenic activities. Finally, we show that blood-borne macrophages recruited in late-phase POH are detrimental, and that blockade of their infiltration improves myocardial angiogenesis and ...

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WebNov 12, 2024 · For exam- ple, KLF4 inhibits ischemic stroke-induced apoptosis of cere- bral microvascular endothelial by activating MALAT1 (30). Moreover, KLF4 is a key regulator of macrophage polarization (18) and can regulate microglial activation and subsequent neu- roinﬂammation(16). WebNov 1, 2024 · KLF4 regulates various cell signaling pathways associated with several processes, including the PI3K/AKT pathway [19]. Serotonin 1A receptor (5HT1A) receptors … columbia men\u0027s rapid rivers ii shirt impulse

The Role of KLF4 in Alzheimer’s Disease - PMC - National …

WebMay 9, 2016 · Interaction of malignant glioma cells and microglia. Schematic summary of experimental data revealed that malignant brain tumors secrete the cytokine MIF, which … WebSep 24, 2024 · These microglia boast a gene expression profile that overlaps with the previously described DAM, or disease-activated microglia. The mobilized cells appear sensitized to defend the brain, because they respond better to inflammatory stimuli than do microglia from wild-type mice. WebAug 9, 2024 · KLF4 has been suggested to facilitate the recruitment of transcriptional machinery even to genes within compact chromatin. 31 With KLF4 transactivation of Ch25h in the context of atheroprotective flow, we next examined the epigenetic modulations involved in such activation of the Ch25h gene. columbia men\u0027s rapid rivers pant

Frontiers Transcriptional Regulation of Macrophages

LncRNA MEG3 regulates microglial polarization through …

WebNov 18, 2024 · Given the robust microglial response seen in K2KO mice, we believe that KLF2 serves to regulate aberrant activation of hypothalamic microglia, thereby protecting … WebDec 22, 2015 · LPS has been widely used to study the molecular mechanisms of microglial activation in inflammatory neurodegeneration (1–3).In primary monocultures and … dr. thomas weiler starnbergWebApr 7, 2024 · KLF4 is shown to repress arterial inflammation to regulate neointimal formation following vascular injury by inhibiting tumor necrosis factor-α-induced expression of VCAM- 1 [ 11 ]. KLF4 is also found to be upregulated in the brain following ischemic injury [ … dr thomas weeks atlanta ga

"WebDec 11, 2024 · KLF4 is a vital regulator of macrophage polarization. Studies have shown that KLF4 expression is observably elevated in M2 macrophages and observably reduced in … " - Klf4 microglia

Klf4 microglia

Myeloid Krüppel-like factor 2 is a critical regulator of

WebDec 11, 2024 · This study aimed to explore whether long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) affects the polarization of microglia in cerebral … WebApr 15, 2024 · The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB Signaling Pathway - ScienceDirect Neuroscience Volume 488, 15 April 2024, Pages 102-111 Research Article The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB …

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WebApr 15, 2024 · The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB Signaling Pathway - ScienceDirect … WebApr 1, 2024 · that KLF4 is expressed in microglia and functions as a down- stream factor of TLR signaling, plays critical roles in microglial activation, and ensuing neuroinflammation [ 38 – 41 ].

WebMay 5, 2024 · Microglia are resident macrophage-like immune cells in the central nervous system (CNS) that are important for maintaining homeostasis and normal function of the CNS. Microglia regulate multiple aspects of inflammation, such as cytotoxicity, regeneration, repair and immunosuppression depending on their activation states or phenotypes [10]. WebThe proliferation of NIRG cells and microglia were unaffected by TGFβ-R1 inhibition (Fig. 4c). There was an increase in expression of pS6, a read-out of mTor, following inhibition of TGFβ (Figs. 4d,e). However, expression levels Pax6 and Klf4 were unchanged following SIS3-treatment in NMDA-damaged retinas (Figs. 4, f–i).

WebJun 4, 2024 · Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor expressed in a wide variety of tissues. KLF4 is important for many different physiological processes, … WebApr 14, 2024 · 102.KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress. ... 191.Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses.

WebApr 3, 2024 · Microglia, a population of resident macrophages derived from erythro-myeloid progenitors of the yolk sac ... AHR enhances KLF4 expression and suppresses NF-κB signaling in TAMs.

WebNov 23, 2007 · Krüppel-like factor 4 (KLF4/GKLF/EZF) is a transcription factor involved in both the regulation of proliferation and differentiation in several tissues (1, 2, 3, 4).As a negative regulator of the cell cycle, KLF4 3 activates the expression of p21 Cip1/WAF1, a cyclin-dependent kinase inhibitor (), and represses the expression of cyclin B 1 ().KLF4 is … columbia men\u0027s raven ridge long sleeve shirtWebDec 11, 2024 · We discovered that inhibition of MEG3 could alleviate cerebral I/R injury via inhibiting M1 polarization and promoting M2 polarization through Krüppel-like factor 4 (KLF4), indicating an effective theoretical basis for potential therapeutic targets of cerebral I/R injury. Back to Top Download PDF Metrics dr thomas weber bad oeynhausenWebJun 4, 2024 · KLF4 is important for many different physiological processes, including cell development, stem cell self-renewal, and maintenance of normal tissue homeostasis ( 19 ). Recently, KLF4 has been identified directly bind to promoter region of Agr1, then accelerate its transcription and microglial M2 polarization. columbia men\u0027s redmond mid hiking bootsWebthe role of Klf4 in IL-1b mediated microglial activation. Therefore we focused on IL-1b mediated Klf4 production in murine microglia and sought to understand the role of Klf4 on downstream production of key inﬂammatory markers. Although, a myeloid speciﬁc Klf4 knockdown model has been described recently (Liao et al. 2011), there are no columbia men\u0027s redmond iii hiking shoeWebNational Center for Biotechnology Information columbia men\u0027s ridge gates insulated jacketWebNov 2, 2024 · The translocated IRF2 activated the transcription of Kruppel-like factor 4 (KLF4), causing KLF4 to be induced in BV2. The expression of KLF4 increased the CD206-positive cells in BV2. columbia men\u0027s redmond v2 hiking shoesWebMay 6, 2024 · KLF4 is expressed in a variety of cell types including monocytes/macrophages. Previous reports have demonstrated that KLF4 is expressed in … dr thomas weiner houston