Witryna5 wrz 2024 · GWAS meets transcriptomics. Genome-wide association studies (GWAS) have been able to identify thousands of genetic variants associated with many complex traits. Nevertheless, for many traits such as neuropsychiatric, identified GWAS-hits have very small effect sizes. In addition, their biological interpretation remains challenging … WitrynaThe methodology of transcriptome-wide association studies (TWAS) has become popular in integrating a reference expression quantitative trait (eQTL) data set with an independent main GWAS data set to identify (putatively) causal genes, shedding mechanistic insights to biological pathways from genetic variants to a GWAS trait …
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