WebJan 7, 2024 · The molecular landscape of liver cancer is highly heterogeneous, with extensive inter- and intratumor heterogeneity in genomic, methylomic, transcriptomic, … WebAug 2, 2024 · To characterize the landscape of pharmacogenomic interactions in liver cancers, we developed a protocol to establish human liver cancer cell models at a success rate of around 50% and generated the Liver Cancer Model Repository (LIMORE) with 81 cell models. LIMORE represented genomic and transcriptomic heterogeneity of primary …
The Genomic Landscape of Actinic Keratosis - Academia.edu
WebOct 18, 2024 · One form of liver cancer, known as fibrolamellar hepatocellular carcinoma (FL-HCC), primarily affects young and seemingly healthy people. While a mutation that fuses the genes DNAJB1 and PRKACA have been observed in many of these cases, scientists had yet to show how this fusion event led to liver tumor formation. WebApr 12, 2024 · In this study, we collect placental tissues from cynomolgus macaques at 10 developmental stages of gestation, which is approximately 165 days (Table S2), and establish a comprehensive single-cell transcriptomic landscape of the primate placenta and decidua spanning the entire gestational period.Using bioinformatics analyses and … charms bad luck
Dissecting liver tumor heterogeneity to improve health equity
WebOct 3, 2024 · Purpose Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic microsatellites and is caused by defects in the mismatch repair system. Mismatch repair deficiency that leads to MSI has been well described in several types of human cancer, most frequently in colorectal, endometrial, and gastric adenocarcinomas. … WebAug 1, 2024 · Based on the risk scores, a drug sensitivity analysis was performed using data from LIMORE (Qiu et al., 2024), a pharmacogenomic landscape of human liver cancers. The two drugs with significant ... WebApr 24, 2024 · Epigenetic landscape influences the liver cancer genome architecture Nat Commun. 2024 Apr 24;9(1):1643. doi: 10.1038/s41467-018-03999-y. Authors Natsuko … current santander follow on rate