WebSep 1, 2024 · 配制10%的分离胶和5% 的浓缩胶，每孔加50 μg蛋白上样，进行SDS-PAGE后电转印到PVDF膜，5%脱脂奶粉封闭2 h，加入1∶1 000稀释 的p-PI3K、PI3K、p-Akt、Akt、p-FoxO1、FoxO1、GLUT-2和β-Actin一抗，4 ℃孵育14 h，TBST漂洗后加1∶2 000稀释的HRP-IgG二抗，室温孵育2 h，TBST充分漂洗后加 ... WebFOXM1(Forkhead box protein M1) 是一种转录因子蛋白质，有关调节细胞周期的重要作用。当FOXM1从小鼠中去除后，幼鼠在出生后不久因心臟衰竭而死亡，由于心肌细胞和肝细 …
Cell头条：任红霞等解析控制食欲新机制 - 生物通
WebApr 28, 2016 · FoxO与1433蛋白在胞浆中的结合状态阻止FoxO向核内转运。有人提出1433蛋白与FoxO的结合区是核定位信号(nuclearlocalizationsignal,NLS)输出信号nuclearexportsignal,NES)FoxO可以与1433蛋白解离重新回到核内,或被泛素化后,发生降解,长时间关闭某些基因的表达。 WebFox01 蛋白属于Fox家族，具有多种修饰方式，在糖脂代谢过程中扮演了重要角色。 研究人员发现这小鼠的食欲受到了明显影响，任博士解释道，“缺乏 Fox01的小鼠比正常小鼠吃得更少，也更瘦”，“而且这种小鼠的葡萄糖平衡能力更好，对胰岛素和瘦素的敏感性更 ... give me liberty brief 6th edition
MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal …
WebFOXO1在核与细胞质间来回穿梭，但是作者指出beta细胞与过氧化氢温育之后将诱导FOXO1集中在核内定位。. 伴随这重分配过程的是NeuroD、MafA两个转录因子的直接激 … WebAMPK与2型糖尿病关系研究进展. 关键词:AMPK 2型糖尿病 该付费资源由维普网提供 中国最大最早的专业内容网站...on A K与2MP 型糖尿病关系研究进展 汪茂 荣李蓉 综述 任伟 张素华 审校 .... FoxO1与2型糖尿病关系的研究进展. Fox01与2 型糖尿病关系的研究进展陈丹燕邓华聪 【关键词】Fox01;糖尿病.2型doi:10.3969/j ... Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the … See more Adipogenesis FOXO1 negatively regulates adipogenesis. Presently, the exact mechanism by which this is accomplished is not entirely understood. In the currently accepted model, FOXO1 … See more In its un-phosphorylated state, FOXO1 is localized to the nucleus, where it binds to the insulin response sequence located in the promoter for glucose 6-phosphatase and increases its rate of transcription. FOXO1, through increasing transcription of glucose-6 … See more • Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. • In Gluconeogenesis, FOXO1 gene … See more • FOXO1A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine See more There are three processes, namely acetylation, phosphorylation, and ubiquitination that are responsible for regulation of the activity of forkhead box O1 (FOXO1). See more Because FOXO1 provides a link between transcription and metabolic control by insulin, it is also a potential target for genetic control of type 2 diabetes. In the insulin-resistant … See more FOXO1 has been shown to interact with: • androgen receptor, • estrogen receptor alpha, • CREB-binding protein, and See more further drop