2024 Cisplatin induced hypocalcemia

Cisplatin induced hypocalcemia

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August undefined, 2024

WebSep 4, 2009 · It should be noted that cisplatin causes hypocalcemia in a dose-dependent manner. Indeed, hypocalcemia is a frequent adverse effect of high-dose cisplatin … WebJul 8, 2010 · Cisplatin based therapy for the treatment of solid organ tumors is commonly associated with several renal abnormalities including; *hypokalemia * hypomagnesemia *hypocalcemia *hypophosphatemia *fanconi-like syndrome * acute kidney injury We have all seen these complications on the renal consult service at least once.

DRUG NAME: Cisplatin - BC Cancer

WebMay 19, 2024 · Frequently, hypocalcemia is associated with hypomagnesemia . Cisplatin can decrease 1-alfa-hydroxylation activity and result in low vitamin D3 levels. In cisplatin … WebBoldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats: Role of oxidative stress, inflammation and caspase-3 small warts on face treatment

Hypocalcemia - StatPearls - NCBI Bookshelf

WebJan 12, 2024 · Hypomagnesemia is often associated with hypokalemia (due to urinary potassium wasting) and hypocalcemia (due both to lower parathyroid hormone secretion and end-organ resistance to its effect). (See "Hypomagnesemia: Clinical manifestations of magnesium depletion" .) The major causes of hypomagnesemia will be reviewed in this … WebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced … WebElectrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management. Platinum chemotherapy, particularly cisplatin, is commonly associated with … small warts on fingers

Hypophosphatemia - StatPearls - NCBI Bookshelf

Gitelman-like syndrome after cisplatin therapy: a case report and ...

WebJul 19, 2024 · Usually, the hypocalcemia is resistant to calcium or vitamin D therapy. Normocalcemia and relief of clinical symptoms can be attained by administration of high oral doses of magnesium, up to 20 times the normal intake. ... Cisplatin- and amphotericin B–induced magnesium deficiency is associated with hypocalciuria, which suggests … Webmannitol, or furosemide-induced diuresis is used t o effectively decrease cisplatin-induced nephrotoxicity. 7. Lower doses of cisplatin are given with less intensive hydration. For example, patients receiving doses of 35 mg/m. 2 . ... hypocalcemia may become symptomatic, with muscle irritability or cramps, clonus, tremor, carpopedal spasm and ... small warts on neckWebJul 18, 2024 · Cisplatin causes hypomagnesemia in a dose-dependent fashion and affects up to 90% of patients if no preventive measures are taken (see Section 5 below). 79 The … small warts on ankles

"WebNov 7, 2012 · The cisplatin-induced increase of the Kim-1 expression level suggests that the PST segment is also affected in our study [30, 44]. The NHE3 expression levels were similar in the kidneys of control and cisplatin-treated groups. ... Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the … " - Cisplatin induced hypocalcemia

Cisplatin induced hypocalcemia

An overview of diagnosis and management of drug‐induced hypomagnesemia ...

http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebApr 15, 2024 · Neurologically, very severe hypophosphatemia (<0.6 mg/dL) can contribute to paresthesia, altered mental status, encephalopathy, seizures and coma [ 14 ]. Depletion of ATP in the heart can result in depression of myocardial performance and tachyarrhythmias in patients with serum phosphate ˂1.5 mg/dL [ 15 ].

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WebHypocalcemia is uncommon and has been attributed to hypomagnesemia resulting from use of a chemotherapeutic regimen. Very few publications have described … WebEven after correction of hypomagnesemia and hypocalcemia by magnesium repletion, hypokalemia persisted. Hypokalemia as a consequence of magnesium deficiency is well …

WebCisplatin is a well-known chemotherapeutic agent that can be associated with hyponatremia. Mechanisms of cisplatin-induced hyponatremia include renal salt wasting syndrome (RSWS), and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) (Cheng et al., 2011 ). WebJul 24, 2024 · Cisplatin, a chemotherapeutic drug, can also cause hypocalcemia through hypomagnesemia. Foscarnet can cause …

http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebNational Center for Biotechnology Information

WebFeb 1, 1999 · Hypomagnesemia is a well known side-effect in patients receiving cisplatin-containing chemotherapy. Cisplatin induces hypomagnesemia through its renal toxicity …

small warts on back of handWebMar 8, 2024 · Hypocalcemia may be associated with a spectrum of clinical manifestations, ranging from few (if any) symptoms if the hypocalcemia is mild and/or chronic to … small warts on footWebMar 17, 2016 · It is likely that cisplatin contributed to the profound hypocalcemia in this patient, who presented with a serum Mg of 0.7 mg/dL. Denosumab, a monoclonal … small warts on hands and feetWebApr 10, 2024 · Med-Surg Nursing. Hypocalcemia is when there are low levels of calcium in the blood. Calcium is an electrolyte that plays a vital role in many bodily functions, including muscle contraction, nerve transmission, and bone formation. Various factors, including nutritional deficiencies, medications, and underlying medical conditions, can all lead ... small warts on legsWebApr 5, 2024 · causes of hypocalcemia Severe inflammation (sepsis, major burns). Pancreatitis (especially: hypertriglyceridemic pancreatitis). Citrate (massive transfusion, plasmapheresis, leukapheresis, renal replacement therapy). Ethylene glycol poisoning. Alkalosis: Respiratory alkalosis (e.g., panic-induced). small warts on hands picturesWebJul 18, 2024 · Cisplatin causes hypomagnesemia in a dose‐dependent fashion and affects up to 90% of patients if no preventive measures are taken (see Section 5 below). 79 The etiology of cisplatin‐induced hypomagnesemia is not completely understood; renal Mg loss is the primary mechanism, but gastrointestinal losses have also been reported. 80 ... small warts on neck picturesWebMar 9, 2024 · Cisplatin is a clinically advanced and highly effective anticancer drug that is used for the treatment of various solid tumors, such as lung cancer, stomach cancer, and ovarian cancer [1]. However, nephrotoxicity is the … small warts on palm of hand