WebJun 18, 2014 · Initiate phenytoin therapy or any other alternative anti-convulsant prophylactic therapy (e.g., benzodiazepines, valproic acid or levetiracetam) prior to Busulfan Injection treatment [see Dosage and Administration (2.1)]. Use caution when administering the recommended dose of Busulfan Injection to patients with a history of a seizure disorder ... WebWe develop a population pharmacokinetic model to describe Busulfan pharmacokinetics in paediatric patients and investigate by simulations the impact of various sampling schedules on the calculation of AUC. Seventy-six children had 2 h infusions every 6 h. A two-compartment linear model was found to adequately describe the data. A lag-time was …
Development of a Population Pharmacokinetic Model of Busulfan …
WebBusulfan . Metronidazole has been reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity. Metronidazole should not be administered concomitantly with busulfan unless the benefit outweighs the risk. ... There is some indication from controlled comparative studies that cure ... WebMay 18, 2024 · Administer Busulfan Injection in combination with cyclophosphamide as a conditioning regimen prior to bone marrow or peripheral blood progenitor cell replacement. For patients weighing more than 12 kg, the recommended doses are: — Busulfan Injection 0.8 mg per kg (ideal body weight or actual body weight, whichever is lower) intravenously … kanye remote control
Use of busulfan in conditioning for allogeneic hematopoietic
WebJun 18, 2014 · Busulfan is a mutagen and a clastogen. In in vitro tests it caused mutations in Salmonella typhimurium and Drosophila melanogaster. Chromosomal aberrations induced by busulfan have been reported in vivo (rats, mice, hamsters, and humans) and in vitro (rodent and human cells). The intravenous administration of busulfan (48 mg/kg given as ... Web-Busulfan dosing protocol must be intravenous administration of 0.8 mg/kg doses every 6 hours over 4 days, for a total of 16 doses-Specimens must be collected as described below: Â -1 specimen collected immediately after completion of the first 2-hour IV infusion of busulfan. Â -1 specimen collected 1 hour after the infusion is completed WebOct 12, 2024 · Busulfan has a mean elimination half life of between 2.3 and 2.8 h. Adult patients have demonstrated a clearance of busulfan of 2.4 to 2.6 ml/min/kg. The elimination half life of busulfan has been reported to decrease upon repeat dosing suggesting that busulfan potentially increases its own metabolism. kanye records